https://clinicaltrials.gov/ct2/show/NCT02313350 http://www.Clinicaltrials.gov https://clinicaltrials.gov/ct2/show/NCT02313350 http://www.Clinicaltrials.gov https://clinicaltrials.gov/ct2/show/study/NCT01873404 https://clinicaltrials.gov/ct2/show/study/NCT01873404 http://www.Clinicaltrials.gov https://www.Clinicaltrials.gov/ct2/show/NCT02528253 http://www.Clinicaltrials.gov https://www.clinicaltrials.gov/ct2/show/record/NCT02412735 https://www.clinicaltrials.gov/ct2/show/record/NCT02412735