American Society of Regional Anesthesia and Pain Medicine May 2017 - 12

Table 1: Summary of published work on stellate ganglion blocks and posttraumatic stress disorder.
Author/year

Patient population

Study type

n

Conclusions

Lebovits et al, 1990

CRPS and PTSD
15 y/o s/p GSW in RUE. Series
of 13 SGB injections for CRPS
treatment.

Case report

1

Lipov et al, 2008

PTSD

Letter to editor

1

Lipov et al, 2009

Unifying theory on SGB, CRPS,
hot flashes, and PTSD

Hypothesis

n/a

Animal model of central
representation of sympathetic
nervous system (2001)

Lipov et al, 2010

Pulsed radio frequency to the
SGB for PTSD

Case report

1

Symptom diary: 1 week: 10%
of anxiety; 50% appetite; 25%
sleep

Mulvaney et al, 2010

Panic/anxiety symptoms of
PTSD

Case series: prospective

2

Lipov, 2010

PTSD: Can the SGB be the
answer?

Editorial

n/a

n/a

Alino, 2011

Misleading conclusion from
unifying theory

Hypothesis

n/a

Central projections unknown:
previous study based on rabies
virus (retrograde)

Lipov et al, 2012

Novel application: preliminary
observation of treatment of
PTSD

Case series: retro

8

PCL-M pre: 67.8 (55-79)
PCL-M post: 35.3 (21-63)
* Average follow-up 17.5 days
(1-59)

Hickey et al, 2012

PTSD

Case series: letter to editor

9

CAPS score: Baseline/1
week/4-6 weeks
Success > 30% reduction: 56%

Lipov et al, 2012

Modulation of NGF and SGB -
link between memory and PTSD

Hypothesis

n/a

Same as 2009 article

Need to diagnose PTSD in pain
patients; unlikely to decrease
pain without treating both

PCL: 50% reduction
Meds: 100% reduction

PCL-M: Pre (71)/post (40)
Lipov et al, 2013

Refractory PTSD and memory

Case report

1

RAVLT: Immediate 3 -> 6/15
-> 15
Alcoholism: now a social drinker

Alino et al, 2013

PTSD - military trauma

Case report

4

PCL-M pre procedure
(1-3 days): > 50
PCL-M post procedure
(1-3 days): < 24*
* Post PCL-M not recorded in 25%

CAPS - Clinician-Administered PTSD Scale; CRPS - complex regional pain syndrome; NGF - nerve growth factor; PCL-M - PTSD CheckList - Military
version; PTSD - post-traumatic stress disorder; RAVLT - Rey Auditory Verbal Learning Test; SGB - stellate ganglion block

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2017



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