American Society of Regional Anesthesia and Pain Medicine May 2017 - 12
Table 1: Summary of published work on stellate ganglion blocks and posttraumatic stress disorder.
Author/year
Patient population
Study type
n
Conclusions
Lebovits et al, 1990
CRPS and PTSD
15 y/o s/p GSW in RUE. Series
of 13 SGB injections for CRPS
treatment.
Case report
1
Lipov et al, 2008
PTSD
Letter to editor
1
Lipov et al, 2009
Unifying theory on SGB, CRPS,
hot flashes, and PTSD
Hypothesis
n/a
Animal model of central
representation of sympathetic
nervous system (2001)
Lipov et al, 2010
Pulsed radio frequency to the
SGB for PTSD
Case report
1
Symptom diary: 1 week: 10%
of anxiety; 50% appetite; 25%
sleep
Mulvaney et al, 2010
Panic/anxiety symptoms of
PTSD
Case series: prospective
2
Lipov, 2010
PTSD: Can the SGB be the
answer?
Editorial
n/a
n/a
Alino, 2011
Misleading conclusion from
unifying theory
Hypothesis
n/a
Central projections unknown:
previous study based on rabies
virus (retrograde)
Lipov et al, 2012
Novel application: preliminary
observation of treatment of
PTSD
Case series: retro
8
PCL-M pre: 67.8 (55-79)
PCL-M post: 35.3 (21-63)
* Average follow-up 17.5 days
(1-59)
Hickey et al, 2012
PTSD
Case series: letter to editor
9
CAPS score: Baseline/1
week/4-6 weeks
Success > 30% reduction: 56%
Lipov et al, 2012
Modulation of NGF and SGB -
link between memory and PTSD
Hypothesis
n/a
Same as 2009 article
Need to diagnose PTSD in pain
patients; unlikely to decrease
pain without treating both
PCL: 50% reduction
Meds: 100% reduction
PCL-M: Pre (71)/post (40)
Lipov et al, 2013
Refractory PTSD and memory
Case report
1
RAVLT: Immediate 3 -> 6/15
-> 15
Alcoholism: now a social drinker
Alino et al, 2013
PTSD - military trauma
Case report
4
PCL-M pre procedure
(1-3 days): > 50
PCL-M post procedure
(1-3 days): < 24*
* Post PCL-M not recorded in 25%
CAPS - Clinician-Administered PTSD Scale; CRPS - complex regional pain syndrome; NGF - nerve growth factor; PCL-M - PTSD CheckList - Military
version; PTSD - post-traumatic stress disorder; RAVLT - Rey Auditory Verbal Learning Test; SGB - stellate ganglion block
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2017
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