American Society of Regional Anesthesia and Pain Medicine May 2017 - 38
Table 1: Duration of therapeutic effect of platelet-rich plasma and recounted autologous preparations for patients with knee
osteoarthritis and knee chondropathy.
Investigator
Type of study
Number of patients
Studies that reported 9-12 months of therapeutic effect
Al-Ajlouni J, et al. (2014)
Prospective open-label study
n = 160
Filardo G, et al. (2011)
Prospective observational study
n = 90
Filardo G, et al. (2012)
Randomized controlled trial
n = 144
Gobbi A, et al. (2012)
Observational study
n = 50
Gobbi A, et al. (2015)
Randomized, controlled trial
n = 93
Jang SJ, et al. (2013)
Prospective observational study
n = 65
Raeissadat SA, et al. (2015)
Randomized, controlled trial
n = 160
Hart R, et al. (2013)
Observational study
n = 50
Sampson S, et al. (2010)
Prospective observational study
n = 14
Studies that reported at least 6 months of therapeutic effect
Cerza F, et al. (2012)
Randomized controlled trial
n = 120
Forogh B, et al. (2015)
Randomized controlled trial
n = 44
Gormeli G, et al. (2015)
Randomized controlled trial
n = 162
Guler O, et al. (2015)
Observational study
n = 132
Kon E, et al. (2010)
Prospective observational study
n = 100
Kon E, et al. (2011)
Prospective comparative study
n = 150
Li M, et al. (2011)
Randomized controlled trial
n = 30
Mangone G, et al. (2014)
Observational study
n = 72
Patel S, et al. (2013)
Randomized controlled trial
n = 78
Raeissadat SA, et al. (2013)
Observational study
n = 60
Say F, et al. (2013)
Observational prospective
n = 90
Spakova T, et al. (2012)
Prospective observational study
n = 120
Torrero JI, et al. (2012)
Observational study
n = 30
studies (RCTs). If high-quality RCTs were not available, we included
retrospective studies and other clinical reports. The gathered
literature focused on PRP and related autologous products for
treatment of knee OA and chondropathy.
A total of 24 relevant studies encompassing 2,315 patients
were included in the analysis. The investigations addressed the
duration of clinical effects of injected PRP or recounted autologous
products for knee OA. The outcome measurements in the studies
employed conventional pain and function scales. The methodology
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for PRP preparation, volume of patient's blood obtained, type of
anticoagulant, number and timing of knee injections, and other
options varied significantly between studies. However, there was
a consistent and clinically significant improvement in pain scores
and functional indexes for at least 6 months in all included studies
(Table 1).
Nine of the studies reported decreased therapeutic effect at 12
months after the start of injection therapy; however, in most of the
studies, the pain and functional status scores increased but not to
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