Baylor University Medical Center Proceedings April 2017 - 185

required. Thus, high-pressure liquid chromatography, isoelectric
focusing, hemoglobin DNA sequencing, mass spectrometry,
and matrix-assisted laser desorption/ionization-time of flight
(MALDI-TOF) are now used to differentiate rare mutations not
detected by conventional methods, as in this case (3).
The only other documented case report of Hb Belliard
was published in Hemoglobin (1989) as part of a study to find
hemoglobin disorders within at-risk populations in Brussels (4).
An asymptomatic 20-year-old man of Spanish origin involved
in the study was found to have an incidental alpha chain that
eluted faster than normal and comprised approximately 25% of
the total hemolysate. The abnormality detected was Lys56Asn
and was named after a street (Belliard) in Brussels. To further
investigate the possible inheritance pattern, his father and
brother were also tested and found to have the same mutation.
Other mutations at this same position include Hb Thialand
(Lys56Thr) and Hb Shaare Zedek (Lys56Glu) (4).

Many variants of hemoglobin do not have known clinical
significance; however, with future advances in medicine and
more sophisticated detection of physiologic derangements, this
may not be true. More consistent case reporting may aid in
better understanding of these variants and identification of new
clinical importance.
1.

2.

3.
4.

Focosi D. Homo sapiens diseases-alterations in red blood cells, 2013.
Available at http://www.ufrgs.br/imunovet/molecular_immunology/
pathohomotissueblood_RBC.html; accessed February 8, 2017.
Kjeldsberg CR. Disorders of hemoglobin synthesis. In Practical Diagnosis
of Hematologic Disorders, 4th ed., Vol. 1. Chicago: American Society for
Clinical Pathology:123-140.
Wajcman H, Moradkhani K. Abnormal haemoglobins: detection &
characterization. Indian J Med Res 2011;134:538-546.
Wajcman H, Gombaud-Saintonge G, Galacteros F, Martha M, Vertongen
F. Hb Belliard [alpha 56(E5)Lys-Asn] a new fast-moving alpha chain
variant found in a subject of Spanish origin. Hemoglobin 1989;13(2):157-
162.

Avocations

Ruby-throated hummingbird with bee at trumpet honeysuckle, taken at Stillhouse Hollow Lake, Belton, Texas, on April 25. 2016, with a Canon EOS 5D Mark II
camera and EF70-200 mm lens. Photo by Terry C. Lairmore, MD (Terry.Lairmore@BSWHealth.org), director of surgical oncology at Baylor Scott & White - Temple.
April 2017

 A rare hemoglobin variant, Hb Belliard

185



http://www.ufrgs.br/imunovet/molecular_immunology/pathohomotissueblood_RBC.html http://www.ufrgs.br/imunovet/molecular_immunology/pathohomotissueblood_RBC.html

Table of Contents for the Digital Edition of Baylor University Medical Center Proceedings April 2017

No label
Baylor University Medical Center Proceedings April 2017 - No label
Baylor University Medical Center Proceedings April 2017 - Cover2
Baylor University Medical Center Proceedings April 2017 - 137
Baylor University Medical Center Proceedings April 2017 - 138
Baylor University Medical Center Proceedings April 2017 - 139
Baylor University Medical Center Proceedings April 2017 - 140
Baylor University Medical Center Proceedings April 2017 - 141
Baylor University Medical Center Proceedings April 2017 - 142
Baylor University Medical Center Proceedings April 2017 - 143
Baylor University Medical Center Proceedings April 2017 - 144
Baylor University Medical Center Proceedings April 2017 - 145
Baylor University Medical Center Proceedings April 2017 - 146
Baylor University Medical Center Proceedings April 2017 - 147
Baylor University Medical Center Proceedings April 2017 - 148
Baylor University Medical Center Proceedings April 2017 - 149
Baylor University Medical Center Proceedings April 2017 - 150
Baylor University Medical Center Proceedings April 2017 - 151
Baylor University Medical Center Proceedings April 2017 - 152
Baylor University Medical Center Proceedings April 2017 - 153
Baylor University Medical Center Proceedings April 2017 - 154
Baylor University Medical Center Proceedings April 2017 - 155
Baylor University Medical Center Proceedings April 2017 - 156
Baylor University Medical Center Proceedings April 2017 - 157
Baylor University Medical Center Proceedings April 2017 - 158
Baylor University Medical Center Proceedings April 2017 - 159
Baylor University Medical Center Proceedings April 2017 - 160
Baylor University Medical Center Proceedings April 2017 - 161
Baylor University Medical Center Proceedings April 2017 - 162
Baylor University Medical Center Proceedings April 2017 - 163
Baylor University Medical Center Proceedings April 2017 - 164
Baylor University Medical Center Proceedings April 2017 - 165
Baylor University Medical Center Proceedings April 2017 - 166
Baylor University Medical Center Proceedings April 2017 - 167
Baylor University Medical Center Proceedings April 2017 - 168
Baylor University Medical Center Proceedings April 2017 - 169
Baylor University Medical Center Proceedings April 2017 - 170
Baylor University Medical Center Proceedings April 2017 - 171
Baylor University Medical Center Proceedings April 2017 - 172
Baylor University Medical Center Proceedings April 2017 - 173
Baylor University Medical Center Proceedings April 2017 - 174
Baylor University Medical Center Proceedings April 2017 - 175
Baylor University Medical Center Proceedings April 2017 - 176
Baylor University Medical Center Proceedings April 2017 - 177
Baylor University Medical Center Proceedings April 2017 - 178
Baylor University Medical Center Proceedings April 2017 - 179
Baylor University Medical Center Proceedings April 2017 - 180
Baylor University Medical Center Proceedings April 2017 - 181
Baylor University Medical Center Proceedings April 2017 - 182
Baylor University Medical Center Proceedings April 2017 - 183
Baylor University Medical Center Proceedings April 2017 - 184
Baylor University Medical Center Proceedings April 2017 - 185
Baylor University Medical Center Proceedings April 2017 - 186
Baylor University Medical Center Proceedings April 2017 - 187
Baylor University Medical Center Proceedings April 2017 - 188
Baylor University Medical Center Proceedings April 2017 - 189
Baylor University Medical Center Proceedings April 2017 - 190
Baylor University Medical Center Proceedings April 2017 - 191
Baylor University Medical Center Proceedings April 2017 - 192
Baylor University Medical Center Proceedings April 2017 - 193
Baylor University Medical Center Proceedings April 2017 - 194
Baylor University Medical Center Proceedings April 2017 - 195
Baylor University Medical Center Proceedings April 2017 - 196
Baylor University Medical Center Proceedings April 2017 - 197
Baylor University Medical Center Proceedings April 2017 - 198
Baylor University Medical Center Proceedings April 2017 - 199
Baylor University Medical Center Proceedings April 2017 - 200
Baylor University Medical Center Proceedings April 2017 - 201
Baylor University Medical Center Proceedings April 2017 - 202
Baylor University Medical Center Proceedings April 2017 - 203
Baylor University Medical Center Proceedings April 2017 - 204
Baylor University Medical Center Proceedings April 2017 - 205
Baylor University Medical Center Proceedings April 2017 - 206
Baylor University Medical Center Proceedings April 2017 - 207
Baylor University Medical Center Proceedings April 2017 - 208
Baylor University Medical Center Proceedings April 2017 - 209
Baylor University Medical Center Proceedings April 2017 - 210
Baylor University Medical Center Proceedings April 2017 - 211
Baylor University Medical Center Proceedings April 2017 - 212
Baylor University Medical Center Proceedings April 2017 - 213
Baylor University Medical Center Proceedings April 2017 - 214
Baylor University Medical Center Proceedings April 2017 - 215
Baylor University Medical Center Proceedings April 2017 - 216
Baylor University Medical Center Proceedings April 2017 - 217
Baylor University Medical Center Proceedings April 2017 - 218
Baylor University Medical Center Proceedings April 2017 - 219
Baylor University Medical Center Proceedings April 2017 - 220
Baylor University Medical Center Proceedings April 2017 - 221
Baylor University Medical Center Proceedings April 2017 - 222
Baylor University Medical Center Proceedings April 2017 - 223
Baylor University Medical Center Proceedings April 2017 - 224
Baylor University Medical Center Proceedings April 2017 - 225
Baylor University Medical Center Proceedings April 2017 - 226
Baylor University Medical Center Proceedings April 2017 - 227
Baylor University Medical Center Proceedings April 2017 - 228
Baylor University Medical Center Proceedings April 2017 - 229
Baylor University Medical Center Proceedings April 2017 - 230
Baylor University Medical Center Proceedings April 2017 - 231
Baylor University Medical Center Proceedings April 2017 - 232
Baylor University Medical Center Proceedings April 2017 - 233
Baylor University Medical Center Proceedings April 2017 - 234
Baylor University Medical Center Proceedings April 2017 - 235
Baylor University Medical Center Proceedings April 2017 - 236
Baylor University Medical Center Proceedings April 2017 - 237
Baylor University Medical Center Proceedings April 2017 - 238
Baylor University Medical Center Proceedings April 2017 - 239
Baylor University Medical Center Proceedings April 2017 - 240
Baylor University Medical Center Proceedings April 2017 - 241
Baylor University Medical Center Proceedings April 2017 - 242
Baylor University Medical Center Proceedings April 2017 - 243
Baylor University Medical Center Proceedings April 2017 - 244
Baylor University Medical Center Proceedings April 2017 - 245
Baylor University Medical Center Proceedings April 2017 - 246
Baylor University Medical Center Proceedings April 2017 - 247
Baylor University Medical Center Proceedings April 2017 - 248
Baylor University Medical Center Proceedings April 2017 - 249
Baylor University Medical Center Proceedings April 2017 - 250
Baylor University Medical Center Proceedings April 2017 - 251
Baylor University Medical Center Proceedings April 2017 - 252
Baylor University Medical Center Proceedings April 2017 - Cover3
Baylor University Medical Center Proceedings April 2017 - Cover4
http://www.brightcopy.net/allen/bapr/30-4
http://www.brightcopy.net/allen/bapr/30-3
http://www.brightcopy.net/allen/bapr/30-2
http://www.brightcopy.net/allen/bapr/30-1
http://www.brightcopy.net/allen/bapr/29-4
http://www.brightcopy.net/allen/bapr/29-3
http://www.brightcopy.net/allen/bapr/29-2
http://www.brightcopy.net/allen/bapr/29-1
http://www.brightcopy.net/allen/bapr/28-04
https://www.nxtbook.com/allen/bapr/28-3
https://www.nxtbook.com/allen/bapr/28-2
https://www.nxtbook.com/allen/bapr/28-1
https://www.nxtbook.com/allen/bapr/27-4
https://www.nxtbook.com/allen/bapr/27-3
https://www.nxtbookmedia.com