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Figure. Representative permanent fixation of prostate specimen with immunohistochemical stains: (a) hematoxylin and eosin, (b) Cyclin
D1, (c) CD5, (d) CD20.

MCL is an even rarer entity of prostatic lymphoma,
with only 7 cases reported in the literature (1-7). Th ese
patients typically present with progressive lower urinary
tract symptoms consisting of urgency, frequency, nocturia,
and hematuria, and the lymphoma is discovered after microscopic analysis of resected prostate tissue. Treatment of
known lymphoma of the prostate typically consists of chemotherapy or radiation, with surgery reserved for mechanical obstruction. Lymphoma of the prostate is classiﬁed as
either primary or secondary based on the location discovered
and lack of extraprostatic disease (8). Our patient clearly
had secondary lymphoma given his long history with the
disease.
MCL is a distinct subtype of B-cell non-Hodgkin's lymphoma and comprises 3% to 10% of all lymphomas occurring
in middle-aged to older individuals, with a median age of about
60 years and a marked male predominance (9). MCL generally
has an aggressive clinical course with frequent relapses after
conventional chemotherapy.
The dense, diﬀuse, and monotonous inﬁltrate seen histologically can reliably be diﬀerentiated from other benign confounders (chronic or granulomatous prostatitis) as well as other
mature B-cell lymphomas by positive immunohistochemical

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staining for Cyclin D1, CD5, CD23, and CD10, as well as
negativity for BCL6.
1.

2.
3.

4.
5.

8.
9.

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Mantle cell lymphoma of the prostate gland treated with holmium laser enucleation

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Table of Contents for the Digital Edition of Baylor University Medical Center Proceedings July 2017