Baylor University Medical Center Proceedings July 2017 - 377

option as it regulates the expression of several
cancer-causing genes. Identifying key treatment
targets helps with the development of very
specific, personalized anticancer interventions
that may save more lives in the future."
■ Researchers explore innovative

therapy for treatment-resistant
multiple myeloma
A new clinical trial at Baylor Scott &
White Research Institute is exploring a
novel treatment option for patients with
multiple myeloma. The phase I trial will
evaluate Actimab-M, developed by Actinium
Pharmaceuticals, Inc., in treating patients
with multiple myeloma who are unresponsive
to available therapies. Actimab-M targets the
CD-33 antigen commonly found on blood cells
of myeloid lineage, both malignant and normal.
The drug is an antibody that is bound to
Actinium 225, a potent radioisotope. It delivers
a focal dose of radiation to the target without
affecting surrounding cells and tissues.
"Interestingly, we have found aberrant
expression of this marker on some lymphoid
cancers, including myeloma," said Yair Levy, MD,
director of hematologic malignancies research
at Baylor University Medical Center at Dallas and
principal investigator of the trial. "Research has
shown its presence in cancer cells of 25% to

July 2017

35% of all multiple myeloma patients, making
it a possible target for treatment. In addition, it
also predicts for a more aggressive course of
disease."
In this new trial, Actimab-M will be used
in patients whose myeloma expresses CD33
and who have progressing disease after at
least three prior multiple myeloma therapies.
"This is the first trial in the US to open using
this method of treatment, taking bench
research into the clinic. I am excited to lead
the development of this novel approach," Dr.
Levy said.
■ First-of-its-kind clinical trial for new

pancreatic cancer immunotherapy
underway
Baylor Scott & White Research Institute has
announced a new clinical trial that explores
an innovative immunotherapy treatment for
pancreatic cancer patients-the first of its kind
to enter clinical studies-that allows control
over CAR T-cell activity. The BPX-601 clinical
study, sponsored by Bellicum Pharmaceuticals,
Inc., will evaluate the company's new CAR T-cell
therapy designed to target solid tumors while
giving clinicians control over the expansion and
stimulation of the cells using rimiducid, a small
molecule activator agent. "This clinical trial is an
important step in our ongoing research efforts to

Baylor Scott & White Health news

improve patient outcomes in one of the deadliest
forms of cancer," said Carlos Becerra, MD,
interim chief of oncology at Baylor University
Medical Center and principal investigator of the
study.
■ Researchers receive $12.7M to

improve care for traumatic brain
injury patients
Researchers at Baylor Institute for
Rehabilitation and Baylor Scott & White Research
Institute will participate in a nationwide study
to improve postacute care for patients who
have suffered a traumatic brain injury. The
study is funded by a $12.7 million award from
the Patient-Centered Outcomes Research
Institute, an independent nonprofit organization
established by Congress in 2010. Patients will be
randomized to one of two groups: standardized
discharge care, which includes advice and
referral sources, and standardized discharge
care with a care manager who will assess for
unmet needs and assist with coordination of
care via telephone over 6 months. The project
team will compare functioning and quality of
life at 3, 6, 9, and 12 months in these two
groups. Adding a care coordinator is a model
used regularly by the Veterans Administration
system, but it has not been studied to determine
if it improves outcomes.

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